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葫蘆素B 產品介紹
點擊次數:100 更新時間:2026-08-26

葫蘆素B

分析標準品,HPLC≥97%

Cucurbitacin B

CAS號:6199-67-3

分子式:C32H46O8

分子量:558.71

MDLMFCD07778083

貨號

規格/參數/品牌

價格

貨期

YJ-B20523-5mg

分析標準品,HPLC≥97%

460.00

現貨

YJ-B20523-20mg

分析標準品,HPLC≥97%

900.00

現貨

A10155-20mg

分析標準品,含量86.8%,可溯源

1700.00

現貨

JV30067-5mg

≥98%

469.00

現貨

JV30067-25mg

≥98%

1149.00

現貨

JV30067-100mg

≥98%

3299.00

現貨

 

產品介紹

熔點:184-186℃

沸點:699.3℃ at 760 mmHg

比旋光度:D25 +88° (c = 1.55 in ethanol)

外觀:白色晶體

溶解性:易溶于氯仿

儲存條件:2-8℃

注意:部分產品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。

參考文獻(25)

25. [IF=5.4] Xiao-yu Zhang et al."Unraveling the pharmacodynamic substances and possible mechanism of Trichosanthis Pericarpium in the treatment of coronary heart disease based on plasma pharmacochemistry, network pharmacology and experimental validation."JOURNAL OF E

24. [IF=1.8] Haiqiang Wang et al."Simultaneous determination of four phytoecdysteroids by LC-MS/MS: application to a comparative pharmacokinetic study in normal and adjuvant arthritis rats after oral administration of C. officinalis Kuan phytoecdysteroids extract."XENO

23. [IF=5.895] Qi Wang et al."Discovery and Identification of the Key Contributor to the Bitter Taste in Oriental Melon after Forchlorfenuron Application."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2023;XXXX(XXX):XXX-XXX

22. [IF=5.988] Zhang  Xin et al."Integrating pharmacological evaluation and computational identification for deciphering the action mechanism of Yunpi-Huoxue-Sanjie formula alleviates diabetic cardiomyopathy."Frontiers in Pharmacology.2022 Sep;0:3551

21. [IF=3.391] Jiaxin Xu et al."Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity."Arch Biochem Biophys. 2020 May;684:108314

20. [IF=1.98] Yanting Chai et al."Cucurbitacin B Inhibits the Hippo-YAP Signaling Pathway and Exerts Anticancer Activity in Colorectal Cancer Cells."Med Sci Monitor. 2018; 24: 9251–9258

19. [IF=2.439] Wenjing Ma et al."Cucurbitacin B induces inhibitory effects via the CIP2A/PP2A/C-KIT signaling axis in t(8;21) acute myeloid leukemia."J Pharmacol Sci. 2019 Apr;139:304

18. [IF=3.205] Zhibin Wang et al."Simultaneous determination of cucurbitacin B and cucurbitacin E in rat plasma by UHPLC-MS/MS: A pharmacokinetics study after oral administration of cucurbitacin tablets."J Chromatogr B. 2017 Oct;1065-1066:63

17. [IF=3.267] Pengfei Liu et al."Cucurbitacin B Induces the Lysosomal Degradation of EGFR and Suppresses the CIP2A/PP2A/Akt Signaling Axis in Gefitinib-Resistant Non-Small Cell Lung Cancer."Molecules. 2019 Jan;24(3):647

16. [IF=3.417] Fen  Cai et al."Cucurbitacin B reverses multidrug resistance by targeting CIP2A to reactivate protein phosphatase 2A in MCF-7/adriamycin cells."Oncol Rep. 2016 Aug;36(2):1180-1186

15. [IF=4.784] Shanshan Qin et al."Cucurbitacin B induces inhibitory effects via CIP2A/PP2A/Akt pathway in glioblastoma multiforme."Mol Carcinogen. 2018 Jun;57(6):687-699

14.  Liu, Xuewen, et al. "Cucurbitacin B induces autophagy and apoptosis by suppressing CIP2A/PP2A/mTORC1 signaling axis in human cisplatin resistant gastric cancer cells." Oncology reports 38.1 (2017): 271-278.https:##doi.org/10.3892/or.2017.5648

13.  Qin, Shanshan, et al. "Cucurbitacin B induces inhibitory effects via CIP2A/PP2A/Akt pathway in glioblastoma multiforme." Molecular carcinogenesis 57.6 (2018): 687-699.

12.  Ma, Wenjing, et al. "Cucurbitacin B induces inhibitory effects via the CIP2A/PP2A/C-KIT signaling axis in t (8; 21) acute myeloid leukemia." Journal of pharmacological sciences 139.4 (2019): 304-310.https:##doi.org/10.1016/j.jphs.2018.12.010

11.  Liu, Pengfei, et al. "Cucurbitacin B induces the lysosomal degradation of EGFR and suppresses the CIP2A/PP2A/Akt signaling Axis in Gefitinib-resistant non-small cell lung Cancer." Molecules 24.3 (2019): 647.647; https:##doi.org/10.3390/molecules24030647

10.  Xu, Jiaxin, et al. "Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity." Archives of biochemistry and biophysics 684 (2020): 108314.https:##doi.org/10.1016/j.abb.2020.108314

9.  Chai, Yanting, et al. "Cucurbitacin B inhibits the Hippo-YAP signaling pathway and exerts anticancer activity in colorectal cancer cells." Medical science monitor: international medical journal of experimental and clinical research 24 (2018): 9251.10.12659

8.  Cai, Fen, et al. "Cucurbitacin B reverses multidrug resistance by targeting CIP2A to reactivate protein phosphatase 2A in MCF-7/adriamycin cells." Oncology reports 36.2 (2016): 1180-1186.https:##doi.org/10.3892/or.2016.4892

7.  張雅男  高明潔  祝文博 等. HPLC-UV法同時測定葫蘆素片中葫蘆素B和葫蘆素E的含量[J]. 化學工程師  2018.

6.  周彤,楊書勝,羅明洲,向可,劉瑩,陳森.葫蘆素B通過抑制Hippo-YAP通路抑制結腸癌細胞轉移的機制研究[J].湖北醫藥學院學報,2020,39(01):16-21+2+105.

5.  陳芳, 沈成英, 申寶德,. 葫蘆素B納米混懸凝膠劑的制備及其體外透皮研究[J]. 解放軍藥學學報, 2015(1):49-52.

4.  胡瑞瑞, 張家梁, 郝海軍. 葫蘆素B磷脂復合物納米結構脂質載體的制備[J]. 中成藥, 2019, v.41(11):25-30.

3.  萬露, 肖云芝, 程玲,. 葫蘆素B磷脂復合物制備,表征及體外抗腫瘤活性研究. 中草藥.

2.  季娟麗,張云飛,司淵,劉鵬飛,欽閃閃,劉瑩.葫蘆素B抑制人順鉑耐藥胃癌細胞的作用及機制研究[J].湖北醫藥學院學報,2017,36(05):386-390+403+374.

1.  程玲, 申寶德, 李娟娟,. 外翻腸囊法研究葫蘆素B膽鹽磷脂混合膠束大鼠腸吸收動力學[J]. 中國中藥雜志, 2015, 40(014):2876-2881.

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